{"id":14349,"date":"2017-07-11T08:22:59","date_gmt":"2017-07-11T06:22:59","guid":{"rendered":"http:\/\/innovationsgesellschaft.ch\/?p=14349\/"},"modified":"2017-07-11T08:22:59","modified_gmt":"2017-07-11T06:22:59","slug":"new-baua-report-on-granular-biopersistent-particles-gbp-at-workplaces","status":"publish","type":"post","link":"https:\/\/innovationsgesellschaft.ch\/en\/new-baua-report-on-granular-biopersistent-particles-gbp-at-workplaces\/","title":{"rendered":"New BAuA Report on Granular Biopersistent Particles (GBP) at Workplaces"},"content":{"rendered":"<p>The final report states that the category includes respirable granular biopersistent particles without known significant specific toxicity. This category comprises various materials such as minerals, metals, metal oxides, or polymers that show a negligible solubility in lung fluids (extracellular lung lining fluid, intracellular lysosomal fluid).<\/p>\n<p>The project consists of three modules:<\/p>\n<ul>\n<li><b>Module 1: In vivo study -- Analysis of the bronchoalveolar lavage fluid (BALF) following intratracheal instillation<\/b><\/li>\n<\/ul>\n<p>The analysis of the inflammatory potency of 6 GBP candidates included \u03bc-TiO<sub>2<\/sub>\u00a0\u201cBayertitan T\u201d, nano-TiO2 P25, \u03bc-Eu<sub>2<\/sub>O<sub>3<\/sub>, \u03bc-BaSO<sub>4<\/sub>, \u03bc-ZrO2 and nano-SiO<sub>2<\/sub>, each at a low (0.5 \u03bcl per rat) and high (1.5 \u03bcl) volumetric dose. In the differential cell count, \u03bc-TiO<sub>2<\/sub>\u00a0did not induce statistically significant polymorphonuclear neutrophil (PMN) levels on day 3 post-treatment in the low dose group. The GBP requirement of a very low inflammogenicity was confirmed. PMN levels of approx. 12% in the high dose group indicated a bolus effect. \u03bc-BaSO<sub>4<\/sub>\u00a0showed a behaviour similar to \u03bc-TiO2. In contrast, nano-TiO<sub>2<\/sub>\u00a0P25, \u03bc-Eu<sub>2<\/sub>O<sub>3<\/sub>, \u03bc-ZrO<sub>2<\/sub>\u00a0and nano-SiO<sub>2<\/sub>\u00a0did not meet this GBP criterion.<\/p>\n<ul>\n<li><b>Module 1: In vivo study -- Chemical analysis of the lung burdens<\/b><\/li>\n<\/ul>\n<p>On day 3, an average retention of approx. 70% as compared to the administered total dose was detected; approx. 1\/3 of the dose is eliminated from lungs by rapid clearance mechanisms (coughing, ciliae-mediated processes, etc). The clearance half-time showed a value close to the physiological rat lung clearance of approx. 60 days in the \u03bc-TiO2 \u201cBayertitan T\u201d low dose group. In the high dose group, a doubled half-time was observed (overload effect). In the \u03bc-BaSO4 and amorphous silica groups, smaller values in the range of 25-40 days were calculated indicating an additional dissolution effect. In the \u03bc-Eu2O3 and \u03bc-ZrO2 groups increased half-times, i.e. 4- to 5-fold and 2- to 4-fold, respectively, were calculated indicating a clear surface chemistry-related contribution to the toxic and clearance-retardative outcome. At \u03bc-TiO2 \u201cBayertitan T\u201d and nano-TiO2 P25 very low ionic moieties regarding the total lung burden were detected (\u2264 0.1 weight-% in the 0.5 \u03bcl doses), the other dusts showed higher (0.2-0.7 weight-%) or very high (30 weight-%; Eu2O3) moieties.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><b>Module 2: In vitro assays<\/b><\/li>\n<\/ul>\n<p>The plasmid scission (PSA) and the cytotoxicity assay towards THP-1 cells indicated effects matching to the in vivo results in the Eu<sub>2<\/sub>O<sub>3<\/sub>\u00a0dust group. Overall, in vitro assays under investigation did not mirror the in vivo results with statistically significant power.<\/p>\n<ul>\n<li><b>Module 3: Acellular solubility of test materials<\/b><\/li>\n<\/ul>\n<p>On the basis of the acellular solubility results in artificial lung fluids a threshold value of \u2264 1 mg\/l could be agreed on to define the category of \u201clow soluble particles\u201d.<\/p>\n<p>You can find the full report\u00a0<a href=\"https:\/\/www.baua.de\/DE\/Angebote\/Publikationen\/Berichte\/F2336.pdf;jsessionid=5041A797B126115551B5F969A2DF9693.s2t1?__blob=publicationFile&amp;v=5\" data-htmlarea-external=\"1\">here<\/a>.<\/p>\n<p>&nbsp;<\/p>\n<p><span lang=\"FR-CH\">Source:\u00a0<\/span><a href=\"https:\/\/www.baua.de\/DE\/Angebote\/Publikationen\/Berichte\/F2336.html;jsessionid=12512771DBC2F28F6D99B22D40182DF4.s1t1\" data-htmlarea-external=\"1\"><span lang=\"FR-CH\">https:\/\/www.baua.de\/DE\/Angebote\/Publikationen\/Berichte\/F2336.html;jsessionid=12512771DBC2F28F6D99B22D40182DF4.s1t1<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Germany\u2019s Federal Institute for Occupational Safety and Health (BAuA) has published the final report for the project \u201cMethodology for the Identification of Granular Biopersistent Particles (GBP) at Workplaces\u201d.<\/p>\n","protected":false},"author":22,"featured_media":14333,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[],"class_list":["post-14349","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innovation-society"],"_links":{"self":[{"href":"https:\/\/innovationsgesellschaft.ch\/en\/wp-json\/wp\/v2\/posts\/14349","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/innovationsgesellschaft.ch\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/innovationsgesellschaft.ch\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/innovationsgesellschaft.ch\/en\/wp-json\/wp\/v2\/users\/22"}],"replies":[{"embeddable":true,"href":"https:\/\/innovationsgesellschaft.ch\/en\/wp-json\/wp\/v2\/comments?post=14349"}],"version-history":[{"count":1,"href":"https:\/\/innovationsgesellschaft.ch\/en\/wp-json\/wp\/v2\/posts\/14349\/revisions"}],"predecessor-version":[{"id":14350,"href":"https:\/\/innovationsgesellschaft.ch\/en\/wp-json\/wp\/v2\/posts\/14349\/revisions\/14350"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/innovationsgesellschaft.ch\/en\/wp-json\/wp\/v2\/media\/14333"}],"wp:attachment":[{"href":"https:\/\/innovationsgesellschaft.ch\/en\/wp-json\/wp\/v2\/media?parent=14349"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/innovationsgesellschaft.ch\/en\/wp-json\/wp\/v2\/categories?post=14349"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/innovationsgesellschaft.ch\/en\/wp-json\/wp\/v2\/tags?post=14349"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}